Proton-Activated Chloride Channel: Physiology and Disease

Fanglin Peng; Yi Wu; Xianping Dong; Peng Huang

doi:10.31083/j.fbl2801011

Proton-Activated Chloride Channel: Physiology and Disease

Fanglin Peng, Yi Wu, Xianping Dong, Peng Huang

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

2 Citas (Scopus)

Resumen

The maintenance of intracellular and extracellular pH relies on multiple ion transporters/channels. Proton-activated chloride channel (PAC) precisely regulates extracellular and early/late endosomal pH by transporting chloride ion (Cl-) across membranes and has been shown to be implicated in pH imbalance under hypoxic conditions, such as the acidic microenvironments of cancer and ischemia. In this article, the phenotypic characteristics, molecular mechanisms, physiology of PAC and its role in cancer, ischemic stroke and hypoxia will be discussed in order to provide some clues for developing potential therapeutic strategies.

Idioma original	English
Páginas (desde-hasta)	11
Número de páginas	1
Publicación	Frontiers in Bioscience - Landmark
Volumen	28
N.º	1
DOI	https://doi.org/10.31083/j.fbl2801011
Estado	Published - ene. 16 2023

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Publisher Copyright:
© 2023 The Author(s). Published by IMR Press.

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology

PubMed: MeSH publication types

Journal Article
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AB - The maintenance of intracellular and extracellular pH relies on multiple ion transporters/channels. Proton-activated chloride channel (PAC) precisely regulates extracellular and early/late endosomal pH by transporting chloride ion (Cl-) across membranes and has been shown to be implicated in pH imbalance under hypoxic conditions, such as the acidic microenvironments of cancer and ischemia. In this article, the phenotypic characteristics, molecular mechanisms, physiology of PAC and its role in cancer, ischemic stroke and hypoxia will be discussed in order to provide some clues for developing potential therapeutic strategies.

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Proton-Activated Chloride Channel: Physiology and Disease

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODS de las Naciones Unidas

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