Rapid reversal of internal Na+ and K+ contents of synaptosomes by ouabain

J. T. Archibald; Thomas D. White

doi:10.1038/252595a0

Rapid reversal of internal Na⁺ and K⁺ contents of synaptosomes by ouabain

J. T. Archibald, Thomas D. White

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

THERE is evidence that a number of drugs which have profound effects on the central nervous system (CNS) may do so by altering membrane bound (Na ⁺+K⁺)-dependent ATPase and/or Na⁺ pump activities. For example, ouabain which is an inhibitor of neuronal (Na ⁺+K⁺) dependent ATPase¹ and Na⁺ pump activity², can impair short term memory in small doses³ and produce convulsions when larger doses are administered intraventricularly⁴.

Original language	English
Pages (from-to)	595-596
Number of pages	2
Journal	Nature
Volume	252
Issue number	5484
DOIs	https://doi.org/10.1038/252595a0
Publication status	Published - 1974

ASJC Scopus Subject Areas

General

PubMed: MeSH publication types

Journal Article

Access to Document

10.1038/252595a0

Cite this

@article{d00701e022124322b3f9235a4bef2b7c,

title = "Rapid reversal of internal Na+ and K+ contents of synaptosomes by ouabain",

abstract = "THERE is evidence that a number of drugs which have profound effects on the central nervous system (CNS) may do so by altering membrane bound (Na ++K+)-dependent ATPase and/or Na+ pump activities. For example, ouabain which is an inhibitor of neuronal (Na ++K+) dependent ATPase1 and Na+ pump activity2, can impair short term memory in small doses3 and produce convulsions when larger doses are administered intraventricularly4.",

author = "Archibald, {J. T.} and White, {Thomas D.}",

year = "1974",

doi = "10.1038/252595a0",

language = "English",

volume = "252",

pages = "595--596",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "5484",

}

TY - JOUR

T1 - Rapid reversal of internal Na+ and K+ contents of synaptosomes by ouabain

AU - Archibald, J. T.

AU - White, Thomas D.

PY - 1974

Y1 - 1974

N2 - THERE is evidence that a number of drugs which have profound effects on the central nervous system (CNS) may do so by altering membrane bound (Na ++K+)-dependent ATPase and/or Na+ pump activities. For example, ouabain which is an inhibitor of neuronal (Na ++K+) dependent ATPase1 and Na+ pump activity2, can impair short term memory in small doses3 and produce convulsions when larger doses are administered intraventricularly4.

AB - THERE is evidence that a number of drugs which have profound effects on the central nervous system (CNS) may do so by altering membrane bound (Na ++K+)-dependent ATPase and/or Na+ pump activities. For example, ouabain which is an inhibitor of neuronal (Na ++K+) dependent ATPase1 and Na+ pump activity2, can impair short term memory in small doses3 and produce convulsions when larger doses are administered intraventricularly4.

UR - http://www.scopus.com/inward/record.url?scp=0016315546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016315546&partnerID=8YFLogxK

U2 - 10.1038/252595a0

DO - 10.1038/252595a0

M3 - Article

C2 - 4431524

AN - SCOPUS:0016315546

SN - 0028-0836

VL - 252

SP - 595

EP - 596

JO - Nature

JF - Nature

IS - 5484

ER -