Rapid reversal of internal Na+ and K+ contents of synaptosomes by ouabain

J. T. Archibald; Thomas D. White

doi:10.1038/252595a0

Rapid reversal of internal Na⁺ and K⁺ contents of synaptosomes by ouabain

J. T. Archibald, Thomas D. White

Medicine

Medicine

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47 Citas (Scopus)

Resumen

THERE is evidence that a number of drugs which have profound effects on the central nervous system (CNS) may do so by altering membrane bound (Na ⁺+K⁺)-dependent ATPase and/or Na⁺ pump activities. For example, ouabain which is an inhibitor of neuronal (Na ⁺+K⁺) dependent ATPase¹ and Na⁺ pump activity², can impair short term memory in small doses³ and produce convulsions when larger doses are administered intraventricularly⁴.

Idioma original	English
Páginas (desde-hasta)	595-596
Número de páginas	2
Publicación	Nature
Volumen	252
N.º	5484
DOI	https://doi.org/10.1038/252595a0
Estado	Published - 1974

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