Rapid reversal of internal Na+ and K+ contents of synaptosomes by ouabain

J. T. Archibald; Thomas D. White

doi:10.1038/252595a0

Rapid reversal of internal Na⁺ and K⁺ contents of synaptosomes by ouabain

J. T. Archibald, Thomas D. White

Medicine

Medicine

Résultat de recherche: Article › examen par les pairs

47 Citations (Scopus)

Résumé

THERE is evidence that a number of drugs which have profound effects on the central nervous system (CNS) may do so by altering membrane bound (Na ⁺+K⁺)-dependent ATPase and/or Na⁺ pump activities. For example, ouabain which is an inhibitor of neuronal (Na ⁺+K⁺) dependent ATPase¹ and Na⁺ pump activity², can impair short term memory in small doses³ and produce convulsions when larger doses are administered intraventricularly⁴.

Langue d'origine	English
Pages (de-à)	595-596
Nombre de pages	2
Journal	Nature
Volume	252
Numéro de publication	5484
DOI	https://doi.org/10.1038/252595a0
Statut de publication	Published - 1974

ASJC Scopus Subject Areas

General

PubMed: MeSH publication types

Journal Article

Accès au document

10.1038/252595a0

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