Rat Hepatitis e Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient

Anton Andonov; Mark Robbins; Jamie Borlang; Jingxin Cao; Todd Hatchette; Ashley Stueck; Yvon Deschambault; Kyle Murnaghan; Jessy Varga; Lynn Johnston

doi:10.1093/infdis/jiz025

Rat Hepatitis e Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient

Anton Andonov, Mark Robbins, Jamie Borlang, Jingxin Cao, Todd Hatchette, Ashley Stueck, Yvon Deschambault, Kyle Murnaghan, Jessy Varga, Lynn Johnston

Medicine

Research output: Contribution to journal › Article › peer-review

146 Citations (Scopus)

Abstract

Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan, and the United States, with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains. It is possible that rat HEV is an underrecognized cause of hepatitis infection, and further studies are necessary to elucidate its potential risk and mode of transmission.

Original language	English
Pages (from-to)	951-955
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	220
Issue number	6
DOIs	https://doi.org/10.1093/infdis/jiz025
Publication status	Published - Aug 9 2019

Bibliographical note

Funding Information:
Financial support. This work was supported by the Public Health Agency of Canada.

Publisher Copyright:
© 2019 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

ASJC Scopus Subject Areas

Immunology and Allergy
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiz025

Cite this

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abstract = "Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan, and the United States, with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains. It is possible that rat HEV is an underrecognized cause of hepatitis infection, and further studies are necessary to elucidate its potential risk and mode of transmission.",

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AU - Andonov, Anton

AU - Robbins, Mark

AU - Borlang, Jamie

AU - Cao, Jingxin

AU - Hatchette, Todd

AU - Stueck, Ashley

AU - Deschambault, Yvon

AU - Murnaghan, Kyle

AU - Varga, Jessy

AU - Johnston, Lynn

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Rat Hepatitis e Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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