Rat Hepatitis e Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient

Anton Andonov; Mark Robbins; Jamie Borlang; Jingxin Cao; Todd Hatchette; Ashley Stueck; Yvon Deschambault; Kyle Murnaghan; Jessy Varga; Lynn Johnston

doi:10.1093/infdis/jiz025

Rat Hepatitis e Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient

Anton Andonov, Mark Robbins, Jamie Borlang, Jingxin Cao, Todd Hatchette, Ashley Stueck, Yvon Deschambault, Kyle Murnaghan, Jessy Varga, Lynn Johnston

Medicine

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146 Citas (Scopus)

Resumen

Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan, and the United States, with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains. It is possible that rat HEV is an underrecognized cause of hepatitis infection, and further studies are necessary to elucidate its potential risk and mode of transmission.

Idioma original	English
Páginas (desde-hasta)	951-955
Número de páginas	5
Publicación	Journal of Infectious Diseases
Volumen	220
N.º	6
DOI	https://doi.org/10.1093/infdis/jiz025
Estado	Published - ago. 9 2019

Nota bibliográfica

Funding Information:
Financial support. This work was supported by the Public Health Agency of Canada.

Publisher Copyright:
© 2019 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

ASJC Scopus Subject Areas

Immunology and Allergy
Infectious Diseases

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abstract = "Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan, and the United States, with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains. It is possible that rat HEV is an underrecognized cause of hepatitis infection, and further studies are necessary to elucidate its potential risk and mode of transmission.",

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AU - Andonov, Anton

AU - Robbins, Mark

AU - Borlang, Jamie

AU - Cao, Jingxin

AU - Hatchette, Todd

AU - Stueck, Ashley

AU - Deschambault, Yvon

AU - Murnaghan, Kyle

AU - Varga, Jessy

AU - Johnston, Lynn

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N2 - Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan, and the United States, with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains. It is possible that rat HEV is an underrecognized cause of hepatitis infection, and further studies are necessary to elucidate its potential risk and mode of transmission.

AB - Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan, and the United States, with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains. It is possible that rat HEV is an underrecognized cause of hepatitis infection, and further studies are necessary to elucidate its potential risk and mode of transmission.

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Rat Hepatitis e Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

ODS de las Naciones Unidas

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