Rat Hepatitis e Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient

Anton Andonov; Mark Robbins; Jamie Borlang; Jingxin Cao; Todd Hatchette; Ashley Stueck; Yvon Deschambault; Kyle Murnaghan; Jessy Varga; Lynn Johnston

doi:10.1093/infdis/jiz025

Rat Hepatitis e Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient

Anton Andonov, Mark Robbins, Jamie Borlang, Jingxin Cao, Todd Hatchette, Ashley Stueck, Yvon Deschambault, Kyle Murnaghan, Jessy Varga, Lynn Johnston

Medicine

Résultat de recherche: Article › examen par les pairs

146 Citations (Scopus)

Résumé

Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan, and the United States, with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains. It is possible that rat HEV is an underrecognized cause of hepatitis infection, and further studies are necessary to elucidate its potential risk and mode of transmission.

Langue d'origine	English
Pages (de-à)	951-955
Nombre de pages	5
Journal	Journal of Infectious Diseases
Volume	220
Numéro de publication	6
DOI	https://doi.org/10.1093/infdis/jiz025
Statut de publication	Published - août 9 2019

Note bibliographique

Funding Information:
Financial support. This work was supported by the Public Health Agency of Canada.

Publisher Copyright:
© 2019 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

ASJC Scopus Subject Areas

Immunology and Allergy
Infectious Diseases

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1093/infdis/jiz025

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abstract = "Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan, and the United States, with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains. It is possible that rat HEV is an underrecognized cause of hepatitis infection, and further studies are necessary to elucidate its potential risk and mode of transmission.",

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AU - Andonov, Anton

AU - Robbins, Mark

AU - Borlang, Jamie

AU - Cao, Jingxin

AU - Hatchette, Todd

AU - Stueck, Ashley

AU - Deschambault, Yvon

AU - Murnaghan, Kyle

AU - Varga, Jessy

AU - Johnston, Lynn

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N2 - Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan, and the United States, with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains. It is possible that rat HEV is an underrecognized cause of hepatitis infection, and further studies are necessary to elucidate its potential risk and mode of transmission.

AB - Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan, and the United States, with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains. It is possible that rat HEV is an underrecognized cause of hepatitis infection, and further studies are necessary to elucidate its potential risk and mode of transmission.

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Rat Hepatitis e Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient

Résumé

Note bibliographique

ASJC Scopus Subject Areas

ODD de l’ONU

Accès au document

Autres fichiers et liens

Empreinte numérique

Citer