Two formulations of the agricultural pesticide adjuvant, Toximul™, reduce the glycogen content of HepG2 cells

Mustafa Al-Khalidi; Philip D. Acott; John F.S. Crocker; Laurette Geldenhuys; Patrick A. O'Regan; Jacqueline Upham; Mary G. Murphy

doi:10.1080/10937400601171340

Two formulations of the agricultural pesticide adjuvant, Toximul™, reduce the glycogen content of HepG2 cells

Mustafa Al-Khalidi, Philip D. Acott, John F.S. Crocker, Laurette Geldenhuys, Patrick A. O'Regan, Jacqueline Upham, Mary G. Murphy

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Young mice exposed dermally to the Toximul™ (Tox) class of agricultural pesticide adjuvants have reduced levels of hepatic glycogen, a marker of subclinical toxicity. The present study determined whether these effects on glycogen also occurred in cultured HepG2 cells. Exposure (3 hr) to Tox resulted in significant, concentration-dependent glycogen reductions (up to 70%) relative to control values (76 ± 3 μg glycogen/mg protein). These reductions did not appear to be due to loss of cell viability, and were reversible with Tox removal. Two different formulations of Tox (3409F and MP-A) differed significantly in the magnitudes of glycogen reduction in the HepG2 cells.

Original language	English
Pages (from-to)	1772-1775
Number of pages	4
Journal	Journal of Toxicology and Environmental Health - Part A: Current Issues
Volume	70
Issue number	20
DOIs	https://doi.org/10.1080/10937400601171340
Publication status	Published - Jan 2007

Bibliographical note

Funding Information:
The authors thank Dr. C. Sinal for providing the HepG2 cells. This study was funded by NSERC and the Nova Scotia Health Research Foundation.

ASJC Scopus Subject Areas

Toxicology
Health, Toxicology and Mutagenesis

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10.1080/10937400601171340

Cite this

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title = "Two formulations of the agricultural pesticide adjuvant, Toximul{\texttrademark}, reduce the glycogen content of HepG2 cells",

abstract = "Young mice exposed dermally to the Toximul{\texttrademark} (Tox) class of agricultural pesticide adjuvants have reduced levels of hepatic glycogen, a marker of subclinical toxicity. The present study determined whether these effects on glycogen also occurred in cultured HepG2 cells. Exposure (3 hr) to Tox resulted in significant, concentration-dependent glycogen reductions (up to 70%) relative to control values (76 ± 3 μg glycogen/mg protein). These reductions did not appear to be due to loss of cell viability, and were reversible with Tox removal. Two different formulations of Tox (3409F and MP-A) differed significantly in the magnitudes of glycogen reduction in the HepG2 cells.",

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note = "Funding Information: The authors thank Dr. C. Sinal for providing the HepG2 cells. This study was funded by NSERC and the Nova Scotia Health Research Foundation.",

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AU - Al-Khalidi, Mustafa

AU - Acott, Philip D.

AU - Crocker, John F.S.

AU - Geldenhuys, Laurette

AU - O'Regan, Patrick A.

AU - Upham, Jacqueline

AU - Murphy, Mary G.

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AB - Young mice exposed dermally to the Toximul™ (Tox) class of agricultural pesticide adjuvants have reduced levels of hepatic glycogen, a marker of subclinical toxicity. The present study determined whether these effects on glycogen also occurred in cultured HepG2 cells. Exposure (3 hr) to Tox resulted in significant, concentration-dependent glycogen reductions (up to 70%) relative to control values (76 ± 3 μg glycogen/mg protein). These reductions did not appear to be due to loss of cell viability, and were reversible with Tox removal. Two different formulations of Tox (3409F and MP-A) differed significantly in the magnitudes of glycogen reduction in the HepG2 cells.

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Two formulations of the agricultural pesticide adjuvant, Toximul™, reduce the glycogen content of HepG2 cells

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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