Two formulations of the agricultural pesticide adjuvant, Toximul™, reduce the glycogen content of HepG2 cells

Mustafa Al-Khalidi; Philip D. Acott; John F.S. Crocker; Laurette Geldenhuys; Patrick A. O'Regan; Jacqueline Upham; Mary G. Murphy

doi:10.1080/10937400601171340

Two formulations of the agricultural pesticide adjuvant, Toximul™, reduce the glycogen content of HepG2 cells

Mustafa Al-Khalidi, Philip D. Acott, John F.S. Crocker, Laurette Geldenhuys, Patrick A. O'Regan, Jacqueline Upham, Mary G. Murphy

Medicine

Medicine

Résultat de recherche: Article › examen par les pairs

1 Citation (Scopus)

Résumé

Young mice exposed dermally to the Toximul™ (Tox) class of agricultural pesticide adjuvants have reduced levels of hepatic glycogen, a marker of subclinical toxicity. The present study determined whether these effects on glycogen also occurred in cultured HepG2 cells. Exposure (3 hr) to Tox resulted in significant, concentration-dependent glycogen reductions (up to 70%) relative to control values (76 ± 3 μg glycogen/mg protein). These reductions did not appear to be due to loss of cell viability, and were reversible with Tox removal. Two different formulations of Tox (3409F and MP-A) differed significantly in the magnitudes of glycogen reduction in the HepG2 cells.

Langue d'origine	English
Pages (de-à)	1772-1775
Nombre de pages	4
Journal	Journal of Toxicology and Environmental Health - Part A: Current Issues
Volume	70
Numéro de publication	20
DOI	https://doi.org/10.1080/10937400601171340
Statut de publication	Published - janv. 2007

Note bibliographique

Funding Information:
The authors thank Dr. C. Sinal for providing the HepG2 cells. This study was funded by NSERC and the Nova Scotia Health Research Foundation.

ASJC Scopus Subject Areas

Toxicology
Health, Toxicology and Mutagenesis

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10.1080/10937400601171340

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title = "Two formulations of the agricultural pesticide adjuvant, Toximul{\texttrademark}, reduce the glycogen content of HepG2 cells",

abstract = "Young mice exposed dermally to the Toximul{\texttrademark} (Tox) class of agricultural pesticide adjuvants have reduced levels of hepatic glycogen, a marker of subclinical toxicity. The present study determined whether these effects on glycogen also occurred in cultured HepG2 cells. Exposure (3 hr) to Tox resulted in significant, concentration-dependent glycogen reductions (up to 70%) relative to control values (76 ± 3 μg glycogen/mg protein). These reductions did not appear to be due to loss of cell viability, and were reversible with Tox removal. Two different formulations of Tox (3409F and MP-A) differed significantly in the magnitudes of glycogen reduction in the HepG2 cells.",

author = "Mustafa Al-Khalidi and Acott, {Philip D.} and Crocker, {John F.S.} and Laurette Geldenhuys and O'Regan, {Patrick A.} and Jacqueline Upham and Murphy, {Mary G.}",

note = "Funding Information: The authors thank Dr. C. Sinal for providing the HepG2 cells. This study was funded by NSERC and the Nova Scotia Health Research Foundation.",

year = "2007",

month = jan,

doi = "10.1080/10937400601171340",

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pages = "1772--1775",

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AU - Al-Khalidi, Mustafa

AU - Acott, Philip D.

AU - Crocker, John F.S.

AU - Geldenhuys, Laurette

AU - O'Regan, Patrick A.

AU - Upham, Jacqueline

AU - Murphy, Mary G.

N1 - Funding Information: The authors thank Dr. C. Sinal for providing the HepG2 cells. This study was funded by NSERC and the Nova Scotia Health Research Foundation.

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AB - Young mice exposed dermally to the Toximul™ (Tox) class of agricultural pesticide adjuvants have reduced levels of hepatic glycogen, a marker of subclinical toxicity. The present study determined whether these effects on glycogen also occurred in cultured HepG2 cells. Exposure (3 hr) to Tox resulted in significant, concentration-dependent glycogen reductions (up to 70%) relative to control values (76 ± 3 μg glycogen/mg protein). These reductions did not appear to be due to loss of cell viability, and were reversible with Tox removal. Two different formulations of Tox (3409F and MP-A) differed significantly in the magnitudes of glycogen reduction in the HepG2 cells.

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Two formulations of the agricultural pesticide adjuvant, Toximul™, reduce the glycogen content of HepG2 cells

Résumé

Note bibliographique

ASJC Scopus Subject Areas

Accès au document

Autres fichiers et liens

Empreinte numérique

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