TY - JOUR
T1 - Two formulations of the agricultural pesticide adjuvant, Toximul™, reduce the glycogen content of HepG2 cells
AU - Al-Khalidi, Mustafa
AU - Acott, Philip D.
AU - Crocker, John F.S.
AU - Geldenhuys, Laurette
AU - O'Regan, Patrick A.
AU - Upham, Jacqueline
AU - Murphy, Mary G.
N1 - Funding Information:
The authors thank Dr. C. Sinal for providing the HepG2 cells. This study was funded by NSERC and the Nova Scotia Health Research Foundation.
PY - 2007/1
Y1 - 2007/1
N2 - Young mice exposed dermally to the Toximul™ (Tox) class of agricultural pesticide adjuvants have reduced levels of hepatic glycogen, a marker of subclinical toxicity. The present study determined whether these effects on glycogen also occurred in cultured HepG2 cells. Exposure (3 hr) to Tox resulted in significant, concentration-dependent glycogen reductions (up to 70%) relative to control values (76 ± 3 μg glycogen/mg protein). These reductions did not appear to be due to loss of cell viability, and were reversible with Tox removal. Two different formulations of Tox (3409F and MP-A) differed significantly in the magnitudes of glycogen reduction in the HepG2 cells.
AB - Young mice exposed dermally to the Toximul™ (Tox) class of agricultural pesticide adjuvants have reduced levels of hepatic glycogen, a marker of subclinical toxicity. The present study determined whether these effects on glycogen also occurred in cultured HepG2 cells. Exposure (3 hr) to Tox resulted in significant, concentration-dependent glycogen reductions (up to 70%) relative to control values (76 ± 3 μg glycogen/mg protein). These reductions did not appear to be due to loss of cell viability, and were reversible with Tox removal. Two different formulations of Tox (3409F and MP-A) differed significantly in the magnitudes of glycogen reduction in the HepG2 cells.
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U2 - 10.1080/10937400601171340
DO - 10.1080/10937400601171340
M3 - Article
C2 - 17885934
AN - SCOPUS:34548835011
SN - 1528-7394
VL - 70
SP - 1772
EP - 1775
JO - Journal of Toxicology and Environmental Health - Part A: Current Issues
JF - Journal of Toxicology and Environmental Health - Part A: Current Issues
IS - 20
ER -