Yan, L., Ge, J., Zheng, L., Zhang, Y., Gao, Y., Wang, T., Huang, Y., Yang, Y., Gao, S., Li, M., Liu, Z., Wang, H., Li, Y., Chen, Y., Guddat, L. W., Wang, Q., Rao, Z., & Lou, Z. (2021). Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. Cell, 184(1), 184-193.e10. https://doi.org/10.1016/j.cell.2020.11.016
Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. / Yan, Liming; Ge, Ji; Zheng, Litao et al.
Dans:
Cell, Vol. 184, N° 1, 07.01.2021, p. 184-193.e10.
Résultat de recherche: Article › examen par les pairs
Yan, L, Ge, J, Zheng, L, Zhang, Y, Gao, Y, Wang, T, Huang, Y, Yang, Y, Gao, S, Li, M, Liu, Z, Wang, H, Li, Y, Chen, Y, Guddat, LW, Wang, Q, Rao, Z & Lou, Z 2021, 'Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis', Cell, vol. 184, n° 1, pp. 184-193.e10. https://doi.org/10.1016/j.cell.2020.11.016
Yan L, Ge J, Zheng L, Zhang Y, Gao Y, Wang T et al. Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. Cell. 2021 janv. 7;184(1):184-193.e10. doi: 10.1016/j.cell.2020.11.016
Yan, Liming ; Ge, Ji ; Zheng, Litao et al. / Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. Dans: Cell. 2021 ; Vol. 184, N° 1. pp. 184-193.e10.
@article{11027fe3e7764db8aa97f53eb42024cb,
title = "Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis",
abstract = "Yan et al. present a cryo-EM structure of the SARS-CoV-2 replication and transcription complex that includes the single RNA-binding protein nsp9. The structural snapshot provides insight into how the viral machinery catalyzes a crucial step in viral mRNA cap synthesis, which is important for virus survival.",
author = "Liming Yan and Ji Ge and Litao Zheng and Ying Zhang and Yan Gao and Tao Wang and Yucen Huang and Yunxiang Yang and Shan Gao and Mingyu Li and Zhenyu Liu and Haofeng Wang and Yingjian Li and Yu Chen and Guddat, {Luke W.} and Quan Wang and Zihe Rao and Zhiyong Lou",
note = "Funding Information: We thank Prof. Haiteng Deng and Dr. Meng Han of Tsinghua University for their assistance for mass spectrum analysis. We also must express our gratitude to the Bio-Electron Microscopy Facility of ShanghaiTech University for data collection. This work was supported by the National Program on Key Research Project of China ( 2020YFA0707500 and 2017YFC0840300 ) and Tsinghua University Spring Breeze Fund . Funding Information: We thank Prof. Haiteng Deng and Dr. Meng Han of Tsinghua University for their assistance for mass spectrum analysis. We also must express our gratitude to the Bio-Electron Microscopy Facility of ShanghaiTech University for data collection. This work was supported by the National Program on Key Research Project of China (2020YFA0707500 and 2017YFC0840300) and Tsinghua University Spring Breeze Fund. Z.R. and Z. Lou conceived the project and designed the experiments. L.Y. J.G. L.Z. Y.Z. Y.G. T.W. Y.Y. S.G. M.L. Z. Liu, H.W. and Y.L. performed experiments. L.Y. Y.H. Y.C. Q.W. Z. Lou, and Z.R. analyzed the data. Z.R. Z. Lou, L.Y. and L.W.G. wrote the manuscript. All authors discussed the experiments and read and approved the manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = jan,
day = "7",
doi = "10.1016/j.cell.2020.11.016",
language = "English",
volume = "184",
pages = "184--193.e10",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "1",
}
TY - JOUR
T1 - Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis
AU - Yan, Liming
AU - Ge, Ji
AU - Zheng, Litao
AU - Zhang, Ying
AU - Gao, Yan
AU - Wang, Tao
AU - Huang, Yucen
AU - Yang, Yunxiang
AU - Gao, Shan
AU - Li, Mingyu
AU - Liu, Zhenyu
AU - Wang, Haofeng
AU - Li, Yingjian
AU - Chen, Yu
AU - Guddat, Luke W.
AU - Wang, Quan
AU - Rao, Zihe
AU - Lou, Zhiyong
N1 - Funding Information:
We thank Prof. Haiteng Deng and Dr. Meng Han of Tsinghua University for their assistance for mass spectrum analysis. We also must express our gratitude to the Bio-Electron Microscopy Facility of ShanghaiTech University for data collection. This work was supported by the National Program on Key Research Project of China ( 2020YFA0707500 and 2017YFC0840300 ) and Tsinghua University Spring Breeze Fund .
Funding Information:
We thank Prof. Haiteng Deng and Dr. Meng Han of Tsinghua University for their assistance for mass spectrum analysis. We also must express our gratitude to the Bio-Electron Microscopy Facility of ShanghaiTech University for data collection. This work was supported by the National Program on Key Research Project of China (2020YFA0707500 and 2017YFC0840300) and Tsinghua University Spring Breeze Fund. Z.R. and Z. Lou conceived the project and designed the experiments. L.Y. J.G. L.Z. Y.Z. Y.G. T.W. Y.Y. S.G. M.L. Z. Liu, H.W. and Y.L. performed experiments. L.Y. Y.H. Y.C. Q.W. Z. Lou, and Z.R. analyzed the data. Z.R. Z. Lou, L.Y. and L.W.G. wrote the manuscript. All authors discussed the experiments and read and approved the manuscript. The authors declare no competing interests.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/1/7
Y1 - 2021/1/7
N2 - Yan et al. present a cryo-EM structure of the SARS-CoV-2 replication and transcription complex that includes the single RNA-binding protein nsp9. The structural snapshot provides insight into how the viral machinery catalyzes a crucial step in viral mRNA cap synthesis, which is important for virus survival.
AB - Yan et al. present a cryo-EM structure of the SARS-CoV-2 replication and transcription complex that includes the single RNA-binding protein nsp9. The structural snapshot provides insight into how the viral machinery catalyzes a crucial step in viral mRNA cap synthesis, which is important for virus survival.
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U2 - 10.1016/j.cell.2020.11.016
DO - 10.1016/j.cell.2020.11.016
M3 - Article
C2 - 33232691
AN - SCOPUS:85096517151
SN - 0092-8674
VL - 184
SP - 184-193.e10
JO - Cell
JF - Cell
IS - 1
ER -