Identification of a point mutation resulting in loss of cell wall anchoring activity of SrtA of Streptococcus mutans NG5

Song F. Lee, Mary K.H. McGavin

Résultat de recherche: Articleexamen par les pairs

16 Citations (Scopus)

Résumé

Streptococcus mutans NG5 failed to anchor antigen P1 to the cell surface, and such a failure could be attributed to a defective SrtA, which was made defective by a point mutation within the srtA gene. Without a functional SrtA, S. mutans NG5 was not able to perform a number of cell surface-related activities, including saliva-mediated adherence and aggregation.

Langue d'origineEnglish
Pages (de-à)4314-4317
Nombre de pages4
JournalInfection and Immunity
Volume72
Numéro de publication7
DOI
Statut de publicationPublished - juill. 2004

ASJC Scopus Subject Areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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Citer

Lee, S. F., & McGavin, M. K. H. (2004). Identification of a point mutation resulting in loss of cell wall anchoring activity of SrtA of Streptococcus mutans NG5. Infection and Immunity, 72(7), 4314-4317. https://doi.org/10.1128/IAI.72.7.4314-4317.2004