Department of Microbiology & Immunology

2022

ABCDs of the Relative Contributions of Pseudomonas aeruginosa Quorum Sensing Systems to Virulence in Diverse Nonvertebrate Hosts

Vasquez-Rifo, A., Cook, J., McEwan, D. L., Shikara, D., Ausubel, F. M., Di Cara, F. & Cheng, Z., Apr 2022, In: mBio. 13, 2

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Alveolar macrophage metabolic programming via a C-type lectin receptor protects against lipo-toxicity and cell death

Scur, M., Mahmoud, A. B., Dey, S., Abdalbarri, F., Stylianides, I., Medina-Luna, D., Gamage, G. S., Woblistin, A., Wilson, A. N. M., Zein, H. S., Stueck, A., Wight, A., Aguilar, O. A., Di Cara, F., Parsons, B. D., Rahim, M. M. A., Carlyle, J. R. & Makrigiannis, A. P., Dec 2022, In: Nature Communications. 13, 1, 7272.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Citations (Scopus)

Carvacrol Suppresses Inflammatory Biomarkers Production by Lipoteichoic Acid-and Peptidoglycan-Stimulated Human Tonsil Epithelial Cells

Wijesundara, N. M., Lee, S. F., Davidson, R., Cheng, Z. & Vasantha Rupasinghe, H. P., Feb 1 2022, In: Nutrients. 14, 3, 503.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Droplet Digital PCR-Based Detection and Quantification of GyrA Thr-86-Ile Mutation Based Fluoroquinolone-Resistant Campylobacter jejuni

Luo, Y., Zhang, W., Cheng, Y., Lu, Q., Guo, Y., Wen, G., Shao, H., Cheng, Z., Luo, Q. & Zhang, T., Apr 2022, In: Microbiology spectrum. 10, 2

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Lab-scale chemical vapor deposition onto powders

Wang, J. & Obrovac, M. N., Jul 1 2022, In: AIP Advances. 12, 7, 075209.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Mitochondrial damage-associated molecular patterns trigger arginase-dependent lymphocyte immunoregulation

Westhaver, L. P., Nersesian, S., Nelson, A., MacLean, L. K., Carter, E. B., Rowter, D., Wang, J., Gala-Lopez, B. L., Stadnyk, A. W., Johnston, B. & Boudreau, J. E., May 24 2022, In: Cell Reports. 39, 8, 110847.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Citations (Scopus)

Modified protocol for culturing Drosophila S2 R+ cells and adult plasmatocytes to study actin cytoskeleton dynamics

Weaver, C. M., Makdissi, S. & Di Cara, F., Sept 16 2022, In: STAR Protocols. 3, 3, 101588.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses

Nath, A. S., Parsons, B. D., Makdissi, S., Chilvers, R. L., Mu, Y., Weaver, C. M., Euodia, I., Fitze, K. A., Long, J., Scur, M., Mackenzie, D. P., Makrigiannis, A. P., Pichaud, N., Boudreau, L. H., Simmonds, A. J., Webber, C. A., Derfalvi, B., Hammon, Y., Rachubinski, R. A. & Di Cara, F., Mar 1 2022, In: Cell Reports. 38, 9, 110433.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Citations (Scopus)

Natural killer T cell immunotherapy combined with IL-15-expressing oncolytic virotherapy and PD-1 blockade mediates pancreatic tumor regression

Nelson, A., Gebremeskel, S., Lichty, B. D. & Johnston, B., Mar 1 2022, In: Journal for ImmunoTherapy of Cancer. 10, 3

Research output: Contribution to journal › Article › peer-review

Open Access

30 Citations (Scopus)

Peroxisome Injury in Multiple Sclerosis: Protective Effects of 4-Phenylbutyrate in CNS-Associated Macrophages

Roczkowsky, A., Doan, M. A. L., Hlavay, B. A., Mamik, M. K., Branton, W. G., McKenzie, B. A., Saito, L. B., Schmitt, L., Eitzen, G., Di Cara, F., Wuest, M., Wuest, F., Rachubinski, R. & Power, C., Sept 14 2022, In: Journal of Neuroscience. 42, 37, p. 7152-7165 14 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Peroxisomes Regulate Cellular Free Fatty Acids to Modulate Mast Cell TLR2, TLR4, and IgE-Mediated Activation

Meghnem, D., Leong, E., Pinelli, M., Marshall, J. S. & Di Cara, F., May 13 2022, In: Frontiers in Cell and Developmental Biology. 10, 856243.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models

McKeown, B. T., Relja, N. J., Hall, S. R., Gebremeskel, S., Macleod, J. M., Veinotte, C. J., Bennett, L. G., Ohlund, L. B., Sleno, L., Jakeman, D. L., Berman, J. N., Johnston, B. & Goralski, K. B., 2022, In: Canadian Journal of Physiology and Pharmacology. 100, 11, p. 1065-1076 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Production of quorum sensing-related metabolites and phytoalexins during Pseudomonas aeruginosa-Brassica napus interaction

Cook, J., Hui, J. P. M., Zhang, J., Kember, M., Berrué, F., Zhang, J. & Cheng, Z., Aug 1 2022, In: Microbiology (United Kingdom). 168, 8

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Regulation of macrophage-associated inflammatory responses by species-specific lactoferricin peptides

Malone, A., Clark, R. F., Hoskin, D. W. & Power Coombs, M. R., Feb 2022, In: Frontiers in Bioscience - Landmark. 27, 2, 043.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

The identification of Pseudomonas aeruginosa persisters using flow cytometry

Grandy, S., Raudonis, R. & Cheng, Z., 2022, In: Microbiology (United Kingdom). 168, 10, 001252.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

Pringle, E. S., Duguay, B. A., Bui-Marinos, M. P., Mulloy, R. P., Landreth, S. L., Desireddy, K. S., Dolliver, S. M., Ying, S., Caddell, T., Tooley, T. H., Slaine, P. D., Bearne, S. L., Falzarano, D., Corcoran, J. A., Khaperskyy, D. A. & McCormick, C., Sept 1 2022, In: PLoS Pathogens. 18, 9, p. e1010832

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

2021

Carvacrol exhibits rapid bactericidal activity against Streptococcus pyogenes through cell membrane damage

Wijesundara, N. M., Lee, S. F., Cheng, Z., Davidson, R. & Rupasinghe, H. P. V., Dec 2021, In: Scientific Reports. 11, 1, 1487.

Research output: Contribution to journal › Article › peer-review

Open Access

104 Citations (Scopus)

Characterizations of the viability and gene expression of dispersal cells from Pseudomonas aeruginosa biofilms released by alginate lyase and tobramycin

Daboor, S. M., Raudonis, R. & Cheng, Z., Oct 2021, In: PLoS One. 16, 10 October, e0258950.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate lyase enhances pathogen eradication by antibiotics

Daboor, S. M., Rohde, J. R. & Cheng, Z., Mar 2021, In: Journal of Cystic Fibrosis. 20, 2, p. 264-270 7 p.

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Dual antimicrobial and antiproliferative activity of tcpask peptide derived from a tribolium castaneum insect defensin

Robles-Fort, A., García-Robles, I., Fernando, W., Hoskin, D. W., Rausell, C. & Real, M. D., Feb 2021, In: Microorganisms. 9, 2, p. 1-24 24 p., 222.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)

Natural killer T cell immunotherapy combined with oncolytic vesicular stomatitis virus or reovirus treatments differentially increases survival in mouse models of ovarian and breast cancer metastasis

Gebremeskel, S., Nelson, A., Walker, B., Oliphant, T., Lobert, L., Mahoney, D. & Johnston, B., Mar 15 2021, In: Journal for ImmunoTherapy of Cancer. 9, 3, e002096.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Citations (Scopus)

Recessive Mutations in SYNPO2 as a Candidate of Monogenic Nephrotic Syndrome

Mao, Y., Schneider, R., van der Ven, P. F. M., Assent, M., Lohanadan, K., Klämbt, V., Buerger, F., Kitzler, T. M., Deutsch, K., Nakayama, M., Majmundar, A. J., Mann, N., Hermle, T., Onuchic-Whitford, A. C., Zhou, W., Margam, N. N., Duncan, R., Marquez, J., Khokha, M. & Fathy, H. M. & 10 others, Kari, J. A., El Desoky, S., Eid, L. A., Awad, H. S., Al-Saffar, M., Mane, S., Lifton, R. P., Fürst, D. O., Shril, S. & Hildebrandt, F., Feb 2021, In: Kidney International Reports. 6, 2, p. 472-483 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Si(CO)yNegative Electrodes for Li-Ion Batteries

Cao, Y., Hans, S., Liese, J., Werner-Zwanziger, U., Wang, J., Bennett, J. C., Dunlap, R. A. & Obrovac, M. N., Sept 28 2021, In: Chemistry of Materials. 33, 18, p. 7386-7395 10 p.

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Si85fe15ox alloy anode materials with high thermal stability for lithium ion batteries

Liu, Y., Charlton, M., Wang, J., Bennett, J. C. & Obrovac, M. N., Nov 2021, In: Journal of the Electrochemical Society. 168, 11, 110521.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

The acute phase protein hepcidin is cytotoxic to human and mouse myeloma cells

Conrad, D. M., Hilchie, A. L., Mcmillan, K. A. M., Liwski, R. S., Hoskin, D. W. & Coombs, M. R. P., Feb 2021, In: Anticancer Research. 41, 2, p. 601-608 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

The Natural Alkaloid Piperlongumine Inhibits Metastatic Activity and Epithelial-to-Mesenchymal Transition of Triple-Negative Mammary Carcinoma Cells

Delaney, L. M., Farias, N., Ghassemi Rad, J., Fernando, W., Annan, H. & Hoskin, D. W., 2021, In: Nutrition and Cancer. 73, 11-12, p. 2397-2410 14 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

The Nitric Oxide Donor, S-Nitrosoglutathione, Rescues Peroxisome Number and Activity Defects in PEX1G843D Mild Zellweger Syndrome Fibroblasts

Liu, Y., Weaver, C. M., Sen, Y., Eitzen, G., Simmonds, A. J., Linchieh, L., Lurette, O., Hebert-Chatelain, E., Rachubinski, R. A. & Di Cara, F., Aug 9 2021, In: Frontiers in Cell and Developmental Biology. 9, 714710.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Thiopurines activate an antiviral unfolded protein response that blocks influenza a virus glycoprotein accumulation

Slaine, P. D., Kleer, M., Duguay, B. A., Pringle, E. S., Kadijk, E., Ying, S., Balgi, A., Roberge, M., McCormick, C. & Khaperskyy, D. A., Jun 2021, In: Journal of Virology. 95, 11, e00453.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

Transcriptomic profiling of Brassica napus responses to Pseudomonas aeruginosa

Cook, J., Douglas, G. M., Zhang, J., Glick, B. R., Langille, M. G. I., Liu, K. H. & Cheng, Z., Feb 2021, In: Innate Immunity. 27, 2, p. 143-157 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

2020

Anthocyanin-rich haskap (Lonicera caerulea L.) berry extracts reduce nitrosamine-induced DNA damage in human normal lung epithelial cells in vitro

Amararathna, M., Hoskin, D. W. & Rupasinghe, H. P. V., Jul 2020, In: Food and Chemical Toxicology. 141, 111404.

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

Ontiveros, C. C., Sweeney, C. L., Smith, C., MacIsaac, S., Munoz, S., Davidson, R., McCormick, C., Thomas, N., Davis, I., Stoddart, A. K. & Gagnon, G. A., Aug 2020, In: Environmental Science: Water Research and Technology. 6, 8, p. 2089-2102 14 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Defective influenza a virus rna products mediate mavs-dependent upregulation of human leukocyte antigen class i proteins

Rahim, M. M. A., Parsons, B. D., Price, E. L., Slaine, P. D., Chilvers, B. L., Seaton, G. S., Wight, A., Medina-Luna, D., Dey, S., Grandy, S. L., Anderson, L. E., Cuervo, N. Z., Grandvaux, N., Gaglia, M. M., Kelvin, A. A., Khaperskyy, D. A., McCormick, C. & Makrigiannis, A. P., 2020, In: Journal of Virology. 94, 13, 00165-20.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)

Delivery of apoptosis-inducing piperine to triple-negative breast cancer cells via co-polymeric nanoparticles

Rad, J. G. & Hoskin, D. W., 2020, In: Anticancer Research. 40, 2, p. 689-694 6 p.

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Early growth response 1 deficiency protects the host against pseudomonas aeruginosa lung infection

Pang, Z., Raudonis, R., McCormick, C. & Cheng, Z., Jan 1 2020, In: Infection and Immunity. 88, 1, e00678-19.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Citations (Scopus)

Impaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by inducing upd3 as a peroxikine

Huang, K., Miao, T., Chang, K., Kim, J., Kang, P., Jiang, Q., Simmonds, A. J., Di Cara, F. & Bai, H., Dec 1 2020, In: Nature Communications. 11, 1, 2943.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Citations (Scopus)

Instrumental role for reactive oxygen species in the inflammatory response

Fokam, D. & Hoskin, D., Mar 1 2020, In: Frontiers in Bioscience - Landmark. 25, 6, p. 1110-1119 10 p.

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

MDA-MB-231 breast cancer cells resistant to pleurocidin-family lytic peptides are chemosensitive and exhibit reduced tumor-forming capacity

Hilchie, A. L., Gill, E. E., Power Coombs, M. R., Falsafi, R., Hancock, R. E. W. & Hoskin, D. W., Sept 2020, In: Biomolecules. 10, 9, p. 1-16 16 p., 1220.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

Metabolism and pharmacokinetics of a novel polyphenol fatty acid ester phloridzin docosahexaenoate in Balb/c female mice

Fernando, W., Goralski, K. B., Hoskin, D. W. & Rupasinghe, H. P. V., Dec 2020, In: Scientific Reports. 10, 1, 21391.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Myeloid-derived suppressor cell depletion therapy targets IL-17A-expressing mammary carcinomas

Dawod, B., Liu, J., Gebremeskel, S., Yan, C., Sappong, A., Johnston, B., Hoskin, D. W., Marshall, J. S. & Wang, J., Dec 1 2020, In: Scientific Reports. 10, 1, 13343.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Citations (Scopus)

Myricetin induces apoptosis mediated by oxidative stress in 4T1 and E0771 mammary cancer cells

Knickle, A., Rasmussen, A. & Hoskin, D. W., Jul 1 2020, In: Molecular and Cellular Toxicology. 16, 3, p. 283-289 7 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Peroxisomes in host defense

Di Cara, F., Jul 2020, In: PLoS Pathogens. 16, 7, e1008636.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

Polycistronic genome segment evolution and gain and loss of fast protein function during fusogenic orthoreovirus speciation

Yang, Y., Gaspard, G., McMullen, N., Duncan, R. & Duncan, R., Jul 2020, In: Viruses. 12, 7, 702.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

Raloxifene prevents stress granule dissolution, impairs translational control and promotes cell death during hypoxia in glioblastoma cells

Attwood, K. M., Robichaud, A., Westhaver, L. P., Castle, E. L., Brandman, D. M., Balgi, A. D., Roberge, M., Colp, P., Croul, S., Kim, I., McCormick, C., Corcoran, J. A. & Weeks, A., Nov 2020, In: Cell Death and Disease. 11, 11, 989.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Citations (Scopus)

2019

10-gingerol inhibits ovarian cancer cell growth by inducing G2 arrest

Rasmussen, A., Murphy, K. & Hoskin, D. W., 2019, In: Advanced Pharmaceutical Bulletin. 9, 4, p. 685-689 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

An investigation of the Fe-Mn-Si system for Li-ion battery negative electrodes

Cao, Y., Scott, B., Dunlap, R. A., Wang, J. & Obrovac, M. N., 2019, In: Journal of the Electrochemical Society. 166, 2, p. A21-A26

Research output: Contribution to journal › Article › peer-review

Open Access

18 Citations (Scopus)

Apple peel flavonoid fraction 4 suppresses breast cancer cell growth by cytostatic and cytotoxic mechanisms

Loung, C. Y., Fernando, W., Vasantha Rupasinghe, H. P. & Hoskin, D. W., Sept 13 2019, In: Molecules. 24, 18, 3335.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Citations (Scopus)

Characterization of novel lignocellulose-degrading enzymes from the porcupine microbiome using synthetic metagenomics

Thornbury, M., Sicheri, J., Slaine, P., Getz, L. J., Finlayson-Trick, E., Cook, J., Guinard, C., Boudreau, N., Jakeman, D., Rohde, J. & McCormick, C., Jan 2019, In: PLoS One. 14, 1, e0209221.

Research output: Contribution to journal › Article › peer-review

Open Access